HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → tert-Butyl 3,6-dihydropyridine-1(2H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1,2,3,6-Tetrahydropyridine | HCID 12750 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl 3,6-dihydropyridine-1(2H)-carboxylate | HCID 13094787 | — |
Reaction Steps
To 1.66 g of 1,2,5,6-tetrahydropyridine in 25 ml of CH2Cl2, 2.02 g of N-methylmorpholine are added, the mixture obtained is treated with a solution of 4.36 g (BOC)2O in 30 ml of CH2Cl2 and the mixture obtained is stirred for ca. 36 hours at RT. N-BOC-1,2,5,6-tetrahydropyridine is obtained. 1H-NMR: 5.82(m,1H,HIV), 5.64(m,1H,HIII), 3.86(b,2H,HII), 3.47(t,2H,HVI), 2.12(b,1H,HV), 1.46(m,9H,(CH3)3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612103B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-46b3fbd7136044c5aea1d073388abc42 |
| Source note | uspto-grants-2009_11 |