HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzene-1-carboperoxoic acid → tert-Butyl 7-Oxa-3-azabicyclo(4.1.0)heptane-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzene-1-carboperoxoic acid | HCID 12587398 | — |
| Reactant | tert-Butyl 3,6-dihydropyridine-1(2H)-carboxylate | HCID 13094787 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl 7-Oxa-3-azabicyclo(4.1.0)heptane-3-carboxylate | HCID 21991116 | — |
Reaction Steps
To a solution of 3.29 g of N-BOC-1,2,5,6-tetrahydropyridine in 25 ml of CH2Cl2, a suspension of 6.2 g of chloroperbenzoic acid in 50 ml of CH2Cl2 are added and the mixture obtained is stirred for ca. 12 hours at RT. The mixture obtained is extracted with saturated aqueous NaHCO3-solution and 0.5 m aqueous Na2S5O3-solution and the organic phase obtained is washed, dried and the solvent is evaporated. N-BOC-3,4-epoxy-piperidine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612103B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-572c544fac55488ca52dfdd0c8ea06ea |
| Source note | uspto-grants-2009_11 |