Chlorosulfonic acid → 2-Acetamido-2,3-dihydro-1h-indene-5-sulfonyl chloride

HRID 1432531Notes

Reaction equation

HRID 1432531 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH2:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH:7]1[NH:15][C:16](=[O:18])[CH3:17]>ClCCl>[C:16]([NH:15][CH:7]1[CH2:8][C:9]2[C:14](=[CH:13][CH:12]=[C:11]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:10]=2)[CH2:6]1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamide

Product 1

HCID 203478562-Acetamido-2,3-dihydro-1h-indene-5-sulfonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.6 ml of chloro sulfonic acid was dropped to the stirred solution of 1.06 g N-Indan-2-yl-acetamide and 50 ml of dichloromethane and the mixture was stirred for 15 hours at room temperature. The reaction was than quenched with cold water and die organic phase separated, dried over sodium sulfate evaporated. The resulting residue was used for further reaction without further purification.

Workup

  1. customthan quenched with cold water
  2. customseparated
  3. dry with materialdried over sodium sulfate
  4. customevaporated
  5. customThe resulting residue was used for further reaction without further purification

Sources & evidence

ORD record
ord-778a6159ffd142bd82edd1b722f07a42
Source dataset
uspto-grants-2009_11
Patent number
US07612104B2

Reaction notes

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