1,2-Dichloroethane → N-[4-(N-methyl-N-pyridin-4-yl-amino)phenyl]-2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Participants

Reaction Steps

To a solution of 2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (63 mg, 0.19 mmol) and 4-(N-methyl-N-pyridin-4-yl-amino)phenylamine (47 mg, 0.24 mmol) in DMF (3 mL), EDC (80 mg, 0.42 mmol) was added. The reaction mixture was stirred at room temperature overnight. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (25 mg). MS 512.2 and 514.2 (M+H, Cl pattern).

Provenance & Evidence