反应详情

To a solution of (3S)-2N-(4-chlorophenylaminocarbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (25 mg, 0.064 mmol) and 4-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine (23 mg, 0.13 mmol) in DMF (2 mL) and H2O (0.5 mL) at room temperature, EDC (49 mg, 0.26 mmol) was added. The mixture was stirred at room for 2 h. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (20 mg). MS 548.2 and 550.2 (M+H, Cl pattern).

1. concentrationIt was concentrated in vacuo
2. customThe residue was purified by HPLC