Formaldehyde → (RS)-6-Carboxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Participants

Role	Name	HCID	Charge
Reactant	Formaldehyde	HCID 712	—
Reactant	beta-2-Thienyl-L-alanine	HCID 146719	—
Product	(RS)-6-Carboxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine	HCID 12685848	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

A suspension of (D,L) 3-(2-thienyl)-alanine (302 mg, 1.77 mmol) in 37% aq. HCHO (4 mL) was heated at 60° C. for 2 h. The suspension became clear. It was concentrated in vacuo to give the titled compound (323 mg), which was used in the next step without further purification. MS 184.3 (M+H)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612089B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-a8f032a3ef6c42788b3757bfadf6681b
Source note	uspto-grants-2009_11