HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodoaniline → HCID 69056303, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodoaniline | HCID 10893 | — |
| Reactant | 1,2-Diaminocyclohexane, trans- | HCID 43806 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 4-methyl-2-homopiperazinone | HCID 12236517 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 69056303 | HCID 69056303 | 15.2% |
Reaction Steps
A mixture of 4-iodoaniline (70 mg, 0.32 mmol), 4-methyl-2-homopiperazinone (35 mg, 0.27 mmol), K3PO4 (135 mg, 0.64 mmol) and 1,2-trans-diaminocyclohexane (16 uL, 0.13 mmol) in dioxane (4 mL) was degassed with Ar before being charged with CuI (18 mg, 0.095 mmol). The mixture in a sealed tube was heated at 110 C overnight. The mixture was then purified by a silica gel prep-TLC using CH2Cl2/MeOH (95/5) as solvents to give the titled compound (9 mg). MS 220.5 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612089B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-e3712b00c5f04b2895325644a27b2321 |
| Source note | uspto-grants-2009_11 |