反应详情

温度

110 °C

To a solution of 3-(5-bromo-3-methyl-thiophen-2-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (4.00 g, 10.20 mmol) and AcOH (40 mL) is added Br2 (0.57 mL, 11.21 mmol) and the solution heated at 110° C. overnight. Br2 (0.57 mL, 11.21 mmol) is added and the solution heated at 110° C. for 2 hours. The solution is poured into 5 M NaOH (200 mL) and ice (200 mL). The slurry is extracted with EtOAc (2×150 mL). The combined organic layers are washed with water (200 mL), 20% NaHSO3 (200 mL), sat. NaHCO3 (200 mL) dried over MgSO4, filtered and concentrated. The residue is purified by ISCO (5%-15% EtOAc gradient) furnish the title compound (2.66 g, 5.64 mmol, 55%). 1H NMR (CDCl3) δ 0.86 (t, J=7.5 Hz, 6H), 1.72-1.91 (m, 4H), 2.12 (s, 3H), 2.43 (s, 3H), 2.50 (s, 3H), 3.25-3.35 (m, 1H), 6.69 (s, 1H). LC/MS (m/z): calcd. for C18H21Br2N3S (M+H)+: 470.0; found: 470.3.

1. temperaturethe solution heated at 110° C. for 2 hours
2. extractionThe slurry is extracted with EtOAc (2×150 mL)
3. washThe combined organic layers are washed with water (200 mL), 20% NaHSO3 (200 mL), sat. NaHCO3 (200 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue is purified by ISCO (5%-15% EtOAc gradient)