反应详情

To a solution of 3-(3-chloro-thiophen-2-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine. (1.15 g, 3.44 mmol) and CH2Cl2 (12 mL) is added NBS (0.64 g, 3.62 mmol). The solution is stirred at ambient temperature overnight, washed with water (2×75 mL), brine (75 mL), dried over Na2SO4, filtered and concentrated to furnish the title compound (1.36 g, 3.29 mmol, 96%). 1H NMR (CDCl3), δ 0.88 (t, J=7.5 Hz, 6H), 1.74-1.92 (m, 4H), 2.49 (s, 3H), 2.53 (s, 3H), 3.26-3.36 (m, 1H), 6.70 (s, 1H), 7.07 (s, 1H). LC/MS (m/z): calcd. for C17H19BrClN3S (M+H)+: 412.1; found: 412.0.

1. washwashed with water (2×75 mL), brine (75 mL)
2. dry with materialdried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated