Ammonia → HCID 57932996, compound

Participants

Reaction Conditions

Reaction Steps

50 mg of 8-(1-ethyl-propyl)-3-[2-bromo-4-methyl-5-thiazolyl]-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.13 mmol) and 10 mg of copper (I) oxide are added to 3 ml of 2 M NH3 in MeOH and vial is capped with a Teflon® lined cap, heated at 130° C. for overnight. The reaction mixture is concentrated under N2 gas and applied onto a silica-gel chromatography column (Hexane:AcOEt:2 M NH3 in MeOH=20:20:1) to give 22 mg of the title compound. Yield 54%: mass spectrum (m/e): 330 (M+1); 1H-NMR (CDCl3): 6.72 (s, 1H), 5.24 (br, 2H), 3.40 (m, 1H), 2.56 (s, 3H), 2.47 (s, 3H), 2.18 (s, 3H), 1.85 (m, 4H), 0.90 (t, 6H, J=7.4 Hz).

Provenance & Evidence