Ammonia → HCID 57933083, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (0.22 mmol) of 3-(2,4-Dibromo-thiazol-5-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.22 mmol), 96 mg of morpholine (1.1 mmol) and 215 mg of Cs2CO3 (0.66 mmol) are put in a 4 ml vial with dry THF, and the vial is capped with a Teflon cap. The vial is heated at 120° C. for overnight. The reaction mixture is applied onto a silica-gel chromatography column (Hexane:AcOEt:2 M NH3 in MeOH=9:3:1) to give 72.7 mg of the title compound. Yield 71%. mass spectrum (m/e): 465 (M+1); 1H-NMR (CDCl3): 6.73 (s, 1H), 3.87 (t, 4H, J=5.1 Hz), 3.58 (t, 4H, J=5.1 Hz), 3.35 (m, 1H), 2.57 (s, 3H), 2.53 (s, 3H), 1.86 (m, 4H), 0.90 (t, 6H, J=7.5 Hz).

Provenance & Evidence