Cesium carbonate → HCID 57932974, compound

Participants

Reaction Conditions

Reaction Steps

Using the procedure analogous to Example 257, 8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (200 mg, 0.90 mmol), 4-bromo-3-methyl-5-phenyl isoxazole (430 mg, 1.8 mmol), cesium carbonate (880 mg, 2.70 mmol) and PdCl2(PPh3)2 (25 mg) in DMF (5 ml) are combined and heated at 130° C. for 5 hrs to give the title compound (65 mg, 23% yield). ES-MS (m/z): calc'd for C23H26N4O: 374.5. found 375.1 (M+H)+. 1H NMR (400 mHz, CDCl3): δ 7.50 (d, 2H), 7.31 (m, 3H), 6.69 (s, 1H), 3.39 (m, 1H), 2.48 (s, 3H), 2.20 (s, 6H), 2.33 (s, 3H), 1.84 (m, 4H), 0.88 (m, 6H).

Provenance & Evidence