Methanesulfonic Acid → HCID 131727723, compound

Participants

Reaction Steps

89 mg of N-{5-[8-(1-Ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-4-chloro-thiazol-2-yl}-dimethylamine (0.236 mmol) is dissolved in 2.0 ml of ethylacetate and 0.236 ml of 1M methanesulfonic acid in ethylacetate (0.236 mmol) is added. The solvents are removed under N2 gas and precipitated crystals are collected, washed with Et2O and dried. 92 mg (83%); mass spectrum (m/e): 378 (M+1); 1H-NMR (CDCl3): 7.30 (s, 1H), 3.67 (m, 1H), 3.22 (s, 6H), 2.93 (s, 3H), 2.78 (s, 3H), 2.78 (s, 3H), 2.71 (s, 3H), 1.95 (m, 2H), 1.82 (m, 2H), 0.96 (t, 6H, J=7.3 Hz).

Provenance & Evidence