Dimethylamine → HCID 57933009, compound

Participants

Reaction Conditions

Reaction Steps

67 mg of 3-(2,5-Dibromo-oxazol-4-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.15 mmol), 146 mg of cesium carbonate (0.45 mmol) and 3.0 ml of dimethylamine 2.0M in THF (6 mmol) are placed into a 4 ml of reaction vial and the vial is capped with a Teflon cap. The reaction vial is heated at 130° C. overnight. The reaction mixture is concentrated and applied onto a silica-gel chromatography column (Hexane:AcOE t=3:1) to give 53 mg of the title compound (87%); mass spectrum (m/e): 406; 1H-NMR (CDCl3): 6.72 (s, 1H), 3.37 (m, 1H), 3.15 (s, 6H), 2.58 (s, 3H), 2.53 (s, 3H), 1.85 (m, 4H), 0.90 (t, 6H, J=7.2 Hz).

Provenance & Evidence