Water → HCID 57933027, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(2,4-dibromo-thiazol-5-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (4.86 g, 10.6 mmol) in THF (150 mL) under N2 atmosphere at −78° C., BuLi (6.63 mL 1.6 M in hexane, 10.6 mmol) is added dropwise for a period of 10 minutes. The mixture is stirred at −78° C. for 30 minutes. Water is added, and the mixture is extracted with Et2O (3×100 mL), dried over MgSO4 and concentrated in vacuo. Crude product is purified by flash chromatography on silica gel (eluent hexane:EtOAc 5:1) to give 3.28 g of the title compound (Yield: 82%). ESIMS: m/z 379, 381 [M+H]+.

Provenance & Evidence