Dimethylamine → HCID 57932993, compound

Participants

Reaction Conditions

Reaction Steps

100 mg of 3-(2-Bromo-4-trifluoromethyl-thiazol-5-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.22 mmol) and 218 mg of cesium carbonate (0.66 mmol) are placed in 4 ml reaction vial and 3 ml of dimethylamine 2 M in THF is added. The reaction vial is capped with a Teflon cap and heated at 120° C. overnight. The reaction mixture is filtered and concentrated and applied onto a silica-gel chromatography column (Hexane:AcOEt=3:1) to give 85 mg of the title compound. Yield 94%. mass spectrum (m/e): 412 (M+1).

Provenance & Evidence