(4-Chloro-thiazol-2-yl)-dimethyl-amine → {4-Chloro-5-[8-(1-ethyl-propyl)-6-methyl-2-trifluoromethyl-imidazo[1,2-b]pyridazin-3-yl]-thiazol-2-yl}-dimethyl-amine

Participants

Reaction Steps

Using a procedure analogous to Example 254D, 8-(1-ethyl-propyl)-3-iodo-6-methyl-2-trifluoromethyl-imidazo[1,2-b]pyridazine (250 mg, 0.630 mmol) is coupled with (4-chloro-thiazol-2-yl)-dimethyl-amine (154 mg, 0.945 mmol) to provide desired product. 1H-NMR (CDCl3), δ 0.85 (t, J=7.4 Hz, 6H), 1.83 (m, 4H), 2.55 (s, 3H), 3.16 (s, 6H), 3.31 (m, 1H), 6.81 (s, 1H) ppm. ES-MS (m/z): calcd for C18H21ClF3N5S (M+H)+: 431.91; found: 432.2.

Provenance & Evidence