Bromine → HCID 69007686, compound

HRID 1432777Notes

Reaction equation

HRID 1432777 reaction equation
[Br:1]Br.[CH2:3]([O:5][C:6]1[CH:10]=[CH:9][S:8][C:7]=1[C:11]([O:13][CH3:14])=[O:12])[CH3:4]>C(O)(=O)C>[Br:1][C:9]1[S:8][C:7]([C:11]([O:13][CH3:14])=[O:12])=[C:6]([O:5][CH2:3][CH3:4])[CH:10]=1.[Br:1][C:10]1[C:6]([O:5][CH2:3][CH3:4])=[C:7]([C:11]([O:13][CH3:14])=[O:12])[S:8][CH:9]=1

Participants

5

Reactant 2

HCID 24408BromineHCID 2777650methyl 3-ethoxythiophene-2-carboxylate

Product 2

HCID 69007686HCID 69007686, compoundHCID 69010157HCID 69010157, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine was added to an acetic acid solution of methyl 3-ethoxythiophene-2-carboxylate, followed by stirring at room temperature. The product was separated by silica gel column chromatography to obtain methyl 5-bromo-3-ethoxythiophene-2-carboxylate (F: 265, 267) and methyl 4-bromo-3-ethoxythiophene-2-carboxylate (F: 265, 267).

Workup

  1. customThe product was separated by silica gel column chromatography

Sources & evidence

ORD record
ord-aedeb87595e04fc5bc1aa7f6bbeb2e77
Source dataset
uspto-grants-2009_11
Patent number
US07612108B2

Reaction notes

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