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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1432781Generated: November 4, 2026

Sodium hydride → 3-Fluoro-2-hydroxybenzonitrile

https://huagongshe.com/reaction/1432781

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant2-(Methylsulfonyl)ethanolHCID 84834—
Reactant2,3-DifluorobenzonitrileHCID 88935—
SolventDimethylformamideHCID 6228—
Product3-Fluoro-2-hydroxybenzonitrileHCID 50998841—

Reaction Steps

Sodium hydride was added to a DMF solution of 2,3-difluorobenzonitrile and 2-(methylsulfonyl)ethanol and the whole was stirred at room temperature to obtain 3-fluoro-2-hydroxybenzonitrile. FN: 136.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612108B2
Source datasetuspto-grants-2009_11
ORD IDord-c3aca7559b014b2c887365999421f9c1
Source noteuspto-grants-2009_11