Sodium Hydroxide → HCID 69007705, compound

HRID 1432790Notes

Reaction equation

HRID 1432790 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:14]2[S:18][C:17]([C:19]([OH:21])=[O:20])=[CH:16][CH:15]=2)[CH:6]=[CH:7][C:8]=1[S:9][CH2:10][CH:11]([CH3:13])[CH3:12])#[N:2].[OH-].[Na+:23]>C(O)C>[C:1]([C:3]1[CH:4]=[C:5]([C:14]2[S:18][C:17]([C:19]([O-:21])=[O:20])=[CH:16][CH:15]=2)[CH:6]=[CH:7][C:8]=1[S:9][CH2:10][CH:11]([CH3:13])[CH3:12])#[N:2].[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69007706HCID 69007706, compound

Product 1

HCID 69007705HCID 69007705, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using [3-cyano-4-(isobutylthio)phenyl]boronic acid and methyl 5-bromothiophene-2-carboxylate, 5-[3-cyano-4-(isobutylthio)phenyl]thiophene-2-carboxylic acid was obtained in accordance with the method of Example 2. Then, 333 mg of the resulting 5-[3-cyano-4-(isobutylthio)phenyl]thiophene-2-carboxylic acid was suspended into 10 ml of ethanol, and 1.05 ml of a 1 M aqueous sodium hydroxide solution was added to the suspension, followed by stirring at room temperature for 20 minutes. The reaction solution was concentrated under reduced pressure, the residue was suspended into 2-propanol, and the precipitate was collected by filtration to obtain 256 mg of sodium 5-[3-cyano-4-(isobutylthio)phenyl]thiophene-2-carboxylate.

Workup

  1. additionwas added to the suspension
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-8e6c547bd1da4ee4825f53b6395b87fa
Source dataset
uspto-grants-2009_11
Patent number
US07612108B2

Reaction notes

Loading…