HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 6-Methylquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| Product | 6-Methylquinolin-2(1H)-one | HCID 12237458 | — |
Reaction Steps
The title compound is prepared from p-toluidine and cinnamoyl chloride according to the procedure described in Synthesis 1975, 739. The crude product obtained is triturated in Et2O/hexanes and filtered to give the title compound as a beige solid. 1H NMR (DMSO-d6, 300 MHz) δ11.60 (bs, 1H), 7.82 (d, 1H), 7.41 (s, 1H), 7.30 (d, 1H), 7.18 (d, 1H), 6.45 (d, 1H), 2.30 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612075B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-185242744b1c4d6a9c4b4179f9c6e02c |
| Source note | uspto-grants-2009_11 |