Hydrochloric Acid → HCID 54024436, compound

Participants

Reaction Steps

To a mixture of N-(5-bromo-pyridin-2-yl)-acetamide (1.26 g, 5.86 mmol) and tri-n-butylamine in xylenes (10 mL) is added Pd(OAc)2 (1.4 mg, 0.006 mmol) and triphenyl phosphine (15.4 mg, 0.06 mmol). Acrylic acid (0.48 mL, 7.03 mmol) is then added dropwise over 5 minutes. The mixture is heated to reflux for 5 hours. The solution is cooled to ambient temperatures. The mixture is diluted with water and the pH is adjusted to 4 with 1N HCl. The solution is extracted with EtOAc/CH2Cl2 (2:1). The resulting suspension is filtred to give the title compound (0.80 g, 3.88 mmol) as a white solid. MS (ion spray) 207, (M+H).

Provenance & Evidence