Benzyl chloroformate → HCID 54326145, compound

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Reaction Steps

Benzylchloroformate (1.4 mL, 9.81 mmol) is added dropwise to a solution of N,N-dimethylaminopyridine (1.09 g, 8.93 mmol) and [2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propylamino]-acetic acid methyl ester (3.06 g, 8.12 mmol) in CH2Cl2 at RT. The resulting mixture is stirred overnight then concentrated to dryness. The crude product is purifed by flash chromatography eluting with 1% MeOH/CH2Cl2 to yield the title compound (3.52 g, 6.89 mmol) as a colorless oil. Ion spray MS, [M+H]+=511.

Provenance & Evidence