6-Chlorobenzo[b]thiophene-2-sulfonyl chloride → 6-[4-(6-Chlorobenzo[b]thiophene-2-sulfonyl)-2-oxopiperazin-1-ylmethyl]-1H-quinolin-2-one

HRID 1432947노트

반응식

HRID 1432947 반응식
[O:1]=[C:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=[O:19])[CH:13]=[CH:12]2.NC1C=CC2C(=CC=C(CN3CCNCC3=O)C=2)N=1.[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[CH:47]=[C:46]([S:48](Cl)(=[O:50])=[O:49])[S:45][C:44]=2[CH:52]=1>>[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[CH:47]=[C:46]([S:48]([N:6]3[CH2:5][CH2:4][N:3]([CH2:8][C:9]4[CH:10]=[C:11]5[C:16](=[CH:17][CH:18]=4)[NH:15][C:14](=[O:19])[CH:13]=[CH:12]5)[C:2](=[O:1])[CH2:7]3)(=[O:50])=[O:49])[S:45][C:44]=2[CH:52]=1

참가 물질

4

반응물 3

HCID 151586416-Chlorobenzo[b]thiophene-2-sulfonyl chlorideHCID 179851791-(2-Aminoquinolin-6-ylmethyl)piperazin-2-oneHCID 572013586-(2-oxopiperazin-1-ylmethyl)-1H-quinolin-2-one

생성물 1

HCID 690258756-[4-(6-Chlorobenzo[b]thiophene-2-sulfonyl)-2-oxopiperazin-1-ylmethyl]-1H-quinolin-2-one

실험 절차

The title compound is prepared as described in EXAMPLE 101,using 6-(2-oxopiperazin-1-ylmethyl)-1H-quinolin-2-one, minor product from EXAMPLE 67, Part D, and 6-chlorobenzo[b]thiophene-2-sulfonyl chloride, EXAMPLE 1. The crude product is triturated in CH2Cl2 and filtered to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ11.72 (bs, 1H), 8.33 (s, 1H), 8.18 (s, 1H), 8.07 (d, 1H), 7.78 (d, 1H), 7.58 (dd, 1H), 7.45 (s, 1H), 7.30 (dd, 1H), 7.18 (d, 1H), 6.46 (d, 1H), 4.52 (s, 2H), 3.86 (s, 2H), 3.43 (m, 2H), 3.31 (m, 2H). MS (ion spray) m/z 488, 490, (M+H), Cl pattern.

후처리

  1. customThe title compound is prepared
  2. customThe crude product is triturated in CH2Cl2
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-5826fec45a6748d28ec1f98a0d767a1c
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612075B2

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