HCID 17985192, compound → HCID 53708183, compound

HRID 1432972Notes

Reaction equation

HRID 1432972 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH3:19])[C:14]3=[O:20])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:21][C:22]1[CH:23]=[C:24](/[CH:27]=[CH:28]/[C:29](O)=[O:30])[S:25][CH:26]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:29](=[O:30])[CH:28]=[CH:27][C:24]4[S:25][CH:26]=[C:22]([Cl:21])[CH:23]=4)[C@@H:15]([CH3:19])[C:14]3=[O:20])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 17985192HCID 17985192, compoundHCID 22266172HCID 22266172, compound

Product 1

HCID 53708183HCID 53708183, compound

Procedure

The title compound is prepared as described in EXAMPLE 123, using 1-(4-amino-quinazoline-7-ylmethyl)-3-methyl-piperazine-2-one, EXAMPLE 80, and 3-(4-chloro-thiophen-2-yl)-(E)-acrylic acid, EXAMPLE 26. 1H NMR (d6-DMSO, 300 MHz) δ9.74 (bs, 2H), 8.82 (s, 1H), 8.40 (d, 1H), 7.62 (m, 5H), 7.05 (d, 1H), 4.92 (m, 1H), 4.80 (m, 2H), 4.73 (m, 1H), 4.50 (m, 1H), 3.40 (m, 2H), 1.42 (m, 3H). ESI MS, [M+H]+=442, 444 (Cl pattern).

Sources & evidence

ORD record
ord-5aa224cbba16404fa0a3a0d901c2555d
Source dataset
uspto-grants-2009_11
Patent number
US07612075B2

Reaction notes

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