2-[(5-Chlorothiophen-2-yl)oxy]acetic acid → HCID 9956530、化合物

HRID 1432975ノート

反応式

HRID 1432975 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][CH2:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:23][C:24]1[S:28][C:27]([O:29][CH2:30][C:31](O)=[O:32])=[CH:26][CH:25]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:31](=[O:32])[CH2:30][O:29][C:27]4[S:28][C:24]([Cl:23])=[CH:25][CH:26]=4)[C@@H:15]([CH2:19][CH2:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 111831442-[(5-Chlorothiophen-2-yl)oxy]acetic acidHCID 179852681-(4-Aminoquinazoline-7-ylmethyl)-3-propyl-piperazine-2-one

生成物 1

HCID 9956530HCID 9956530、化合物

実験手順

The title compound is prepared as described in EXAMPLE 123, using 1-(4-aminoquinazoline-7-ylmethyl)-3-propyl-piperazine-2-one, EXAMPLE 78 and 5-chloro-2-thienyloxyacetic acid, EXAMPLE 24. 1H NMR (d6-DMSO, 300 MHz) δ9.78 (bs, 2H), 8.81 (s, 1H), 8.35 (d, 1H), 7.60 (m, 2H), 7.51 (s, 1H), 6.69 (m, 1H), 6.21 (d, 1H), 4.91 (AB, 2H), 4.72 (m, 2H), 3.84 (m, 1H), 3.52 (m, 2H), 3.23 (m, 1H), 1.80 (m, 2H), 1.24 (m, 2H), 0.82 (m, 3H). MS (ion spray), m/z, 474, 476, (M+H) (Cl pattern). Elemental analysis, cal C22H22ClN5O2S.C2HF3O2.1.15H2O % C=47.31, % H=4.52, % N=11.50; found % C=47.39, % H=4.140, % N=11.19.

出典と根拠

ORDレコード
ord-f0c8b4fbe35546b48878659b93b0e1c1
出典データセット
uspto-grants-2009_11
特許番号
US07612075B2

反応ノート

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