1-(4-Aminoquinazoline-7-ylmethyl)-3-propyl-piperazine-2-one → 4-[3-(6-Amino-pyridin-3-yl)-acryloyl]-1-(4-amino-quinazolin-7-ylmethyl)-3-(S)-propyl-piperazin-2-one

Beteiligte Stoffe

Reaktionsschritte

The title compound is prepared as described in EXAMPLE 123, using 1-(4-aminoquinazoline-7-ylmethyl)-3-propyl-piperazine-2-one, EXAMPLE 78 and 3-(6-amino-pyridin-3-yl)-acrylic acid, EXAMPLE 36. 1H NMR (d6-DMSO, 300 MHz) δ9.73 (bs, 2H), 8.81 (s, 1H), 8.36 (m, 2H), 8.22 (m, 3H), 7.62 (d, 1H), 7.52 (m, 1H), 7.39 (m, 1H), 7.21 (m, 1H), 6.91 (d, 1H), 5.00 (m, 1H), 4.78 (m, 1H), 4.60 (m, 2H), 4.34 (m, 1H), 3.30 (m, 2H), 1.87 (m, 2H), 1.24 (m, 2H), 0.90 (m, 3H). MS (ion spray), m/z, 446, 448 (M+H), (Cl pattern).

Herkunft & Nachweise