HCID 17985258, compound → HCID 54053023, compound

HRID 1432980Notes

Reaction equation

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][O:20][CH2:21][CH3:22])[C:14]3=[O:23])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:24][C:25]1[N:30]=[CH:29][C:28]([O:31][CH2:32][C:33](O)=[O:34])=[CH:27][CH:26]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:33](=[O:34])[CH2:32][O:31][C:28]4[CH:29]=[N:30][C:25]([Cl:24])=[CH:26][CH:27]=4)[C@@H:15]([CH2:19][O:20][CH2:21][CH3:22])[C:14]3=[O:23])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 17985258HCID 17985258, compound

HCID 54289059HCID 54289059, compound

Product 1

HCID 54053023HCID 54053023, compound

Procedure

The title compound is prepared as described in EXAMPLE 123, using 1-(4-aminoquinazoline-7-ylmethyl)-3-ethoxymethyl-piperazine-2-one, EXAMPLE 79 and, (6-chloro-pyridin-3-yloxy)-acetic acid, prepared similary to the procedure described in EXAMPLE 29. 1H NMR (d6-DMSO, 300 MHz) δ9.73 (bs, 2H), 8.81 (s, 1H), 8.37 (m, 1H), 8.10 (m, 1H), 7.61 (m, 2H), 7.40 (m, 2H), 4.98 (m, 2H), 4.65 (m, 2H), 4.50 (m, 1H), 3.91 (m, 1H), 3.75 (m, 1H), 3.59 (m, 2H), 3.31 (m, 2H), 1.07 (m, 3H). MS (ion spray), m/z, 485, 487 (M+H), (Cl pattern).

Workup

customprepared similary to the procedure

Sources & evidence

ORD record: ord-675479ddad02441ca0b46f3558bc5ca5
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07612075B2

Reaction notes

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