反应详情

The title compound is prepared as described in EXAMPLE 268, using 1-(4-amino-quinazoline-7-ylmethyl)-3-methoxymethyl-6-methyl-piperazine-2-one, EXAMPLE 87, and 2-bromomethyl-6-chloronaphthalene, EXAMPLE 12. 1H NMR (CDCl3, 300 MHz) δ8.59 (s, 1H), 7.79 (d, 1H), 7.70-7.12 (m, 3H), 7.68-7.67 (m, 2H), 7.55 (d, 1H), 7.39 (d, 1H), 4.78 (d, 2H), 3.98 (d, 2H), 3.44 (s, 3H), 3.38 (t, 1H), 2.64 (m, 2H), 1.26 (d, 3H). MS (ISP) 490, 492, (M+H), Cl pattern.