1-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-6-methyl-piperazine-2-one → HCID 53850872, compound

HRID 1432981Notes

Reaction equation

HRID 1432981 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH:18]([CH3:19])[CH2:17][NH:16][CH:15]([CH2:20][O:21][CH3:22])[C:14]3=[O:23])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Br[CH2:25][C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[C:31]([Cl:36])[CH:32]=2)[CH:27]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[C@@H:18]([CH3:19])[CH2:17][N:16]([CH2:25][C:26]4[CH:35]=[CH:34][C:33]5[C:28](=[CH:29][CH:30]=[C:31]([Cl:36])[CH:32]=5)[CH:27]=4)[C@@H:15]([CH2:20][O:21][CH3:22])[C:14]3=[O:23])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 179852431-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-6-methyl-piperazine-2-oneHCID 536454962-(Bromomethyl)-6-chloronaphthalene

Product 1

HCID 53850872HCID 53850872, compound

Procedure

The title compound is prepared as described in EXAMPLE 268, using 1-(4-amino-quinazoline-7-ylmethyl)-3-methoxymethyl-6-methyl-piperazine-2-one, EXAMPLE 87, and 2-bromomethyl-6-chloronaphthalene, EXAMPLE 12. 1H NMR (CDCl3, 300 MHz) δ8.59 (s, 1H), 7.79 (d, 1H), 7.70-7.12 (m, 3H), 7.68-7.67 (m, 2H), 7.55 (d, 1H), 7.39 (d, 1H), 4.78 (d, 2H), 3.98 (d, 2H), 3.44 (s, 3H), 3.38 (t, 1H), 2.64 (m, 2H), 1.26 (d, 3H). MS (ISP) 490, 492, (M+H), Cl pattern.

Sources & evidence

ORD record
ord-0bb719d165be48008fa7f7e5a505efbb
Source dataset
uspto-grants-2009_11
Patent number
US07612075B2

Reaction notes

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