Pyridine → HCID 54258805, compound

Participants

Reaction Conditions

Reaction Steps

2-Amino-4-[4-(6-chloro-1H-benzoimidazol-2-ylmethyl)-2-oxo-piperidin-1-ylmethyl]-benzonitrile hydrochloric acid salt (70 mg, 0.15 mmol), EXAMPLE 814, Part E, pyridine (1.0 mL) and freshly made chloroformamide hydrochloride (150 mg, 1.33 mmol) are placed in a sealed tube and heated to 200° C. The resulting mixture is heated for twenty four hours. The crude reaction mixture is directly purified by reverse phase HPLC (0-50% ACN/H2O). The product (53 mg, 45% yield) is isolated as a tanish solid. C22H22ClN7O MS m/z: 436,438. Anal. calcd. for C22H22ClN7O: C, 43.23; H, 3.24; N, 12.60. Found: C, 43.16; H, 3.44; N, 13.40.

Provenance & Evidence