Trifluoroacetic acid → HCID 69026655, compound

Participants

Reaction Steps

5-{3-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-yl]-propyl}-imidazol-1carboxylic acid tert-butyl ester (30 mg, 0.055 mmol) is stirred vigorously in a 30% solution of trifluoroacetic acid and methylene chloride (2 mL). The reaction is complete after stirring for three hours. The volatile solvents are removed on the rotovap, and the gummy solid is titurated with ether several times to afford 4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-1-[3-(3H-imidazol-4-yl)-propyl]-piperazin-2-one trifluoroacetic acid salt (30 mg) as a yellow solid. C18H19ClN4O3S2 (m/z)+: 439, 441. Anal cald. for C18H19ClN4O3S2.C2HF3O2: C, 43.44; H, 3.65; N, 10.13. Found C, 42.03; H, 3.55; N, 8.26.

Provenance & Evidence