HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1433134Generated: November 1, 2026
Dimethyl Sulfoxide → Phenyl N-(2-chloro-4-hydroxyphenyl)carbamate
https://huagongshe.com/reaction/1433134
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Chloro-7-methoxyquinoline-6-carboxamide | HCID 22936418 | — |
| Reactant | ME-92 | HCID 23135084 | — |
| Solvent | Water | HCID 962 | — |
| Product | Phenyl N-(2-chloro-4-hydroxyphenyl)carbamate | HCID 11277058 | 142.4% |
Reaction Steps
To dimethyl sulfoxide (20 mL) were added 7-methoxy-4-chloroquinoline-6-carboxamide (0.983 g), 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea (1.13 g) and cesium carbonate (2.71 g), and the mixture was heated and stirred at 70° C. for 23 hours. The reaction mixture was cooled to room temperature, and water (50 mL) was added, and the resultant crystals were then filtered off to give 1.56 g of the titled compound (yield: 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07612208B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-db89dc6381f8450598a79e6ac2611704 |
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| Source note | uspto-grants-2009_11 |
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