HCID 178452255, compound → HCID 178452254, compound

Participants

Reaction Steps

A solution of 4-[3-(2,4-Bis-benzyloxy-5-chloro-phenyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (230 mg, 0.4 mmol) in ethyl acetate (15 ml) was hydrogenated over 10% palladium on carbon for 1.5 h. The suspension was filtered through celite, washing with dichloromethane:ethanol (1:1). The filtrate was concentrated to leave 4-[3-(5-chloro-2,4-dihydroxy-phenyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (Example 1) as a white solid (72 mg)

Provenance & Evidence