Cesium carbonate → HCID 178521212, compound

Participants

Reaction Steps

A mixture of 4-chloro-6-(4-piperazin-1-yl-1H-pyrazol-3-yl)-benzene-1,3-diol (43 mg, 0.146 mmol), cesium carbonate (48 mg, 0.146 mmol), 2-bromoethanol (0.025 ml, 0.35 mmol) and dimethylformamide (1 ml) was stirred at room temperature for 3 days. The mixture was evaporated to dryness and applied to a bond elute cartridge (5 g) with dichloromethane:methanol (49:1), then eluting with dichloromethane followed by dichloromethane:ethanol:ammonia (50:8:1 then 20:8:1) gave 4-chloro-6-{4-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-1H-pyrazol-3-yl}-benzene-1,3-diol as a white solid (10 mg)

Provenance & Evidence