HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorodifluoroacetic acid → HCID 178506054, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorodifluoroacetic acid | HCID 66154 | — |
| Reactant | 4-Bromobenzene-1,2-diamine | HCID 323593 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178506054 | HCID 178506054 | 42% |
Reaction Steps
A mixture of 4-bromo-phenylene-diamine (1.00 g, 5.35 mmol), chlorodifluoroacetic acid (3.0 mL, 35.4 mmol), and a drop of water was heated to 80° C. for 14 hours. The crude product was purified by chromatography (silica, hexanes: EtOAc, 4:1) to afford the title compound as a colorless oil (0.63 g, 42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612211B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-d6d44226716345d1849af3fe87d8e347 |
| Source note | uspto-grants-2009_11 |