反应详情

温度

100 °C

A mixture of [2-tert-butoxycarbonylamino-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester (0.300 g, 0.691 mmol, Example 15, Step A), 2-bromophenylsulfonylethanol (0.153 g, 0.576 mmol), sodium carbonate (0.439 g, 4.15 mmol), and 1,1′-[bis(di-tert-butylphosphino)ferrocene]-palladium dichloride (0.153 g, 0.0576 mmol) in DME (6 mL) and H2O (1.5 mL) was heated at 100° C. for 12 hours. The reaction mixture was concentrated under reduced pressure to provide a residue, which was purified by chromatography (silica, hexanes:EtOAc, 1:1) to afford the title compound as a yellow oil (0.233 g, 82%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customto provide a residue, which
3. customwas purified by chromatography (silica, hexanes:EtOAc, 1:1)