Acetic Acid → HCID 178419329, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-bromo-benzene-1,2-diamine (0.759 g, 4.06 mmol), BOP (1.381 g, 3.12 mmol), and triethylamine (0.44 mL, 3.12 mmol) in acetonitrile (18 mL) were added dropwise over 2 hours a solution of 4-cyclopropyl-phenoxy)-acetic acid (0.600 g, 3.12 mmol) in acetonitrile (5 mL). The reaction mixture was stirred for 12 hours followed by heating at 80° C. for another 8 hours. The reaction mixture was concentrated under reduced pressure to provide a residue, which was purified by chromatography (silica, hexanes: EtOAc=1:1) to afford the title compound as a yellow solid (0.825 g, 77%).

Provenance & Evidence