反应详情

温度

90 °C

Tetrahydropyran-2-ol (2) (14.03 g; 0.138 mol) is added to a benzene solution (300 ml) of (ethoxycarbonylethylidene) triphenylphospholane (64.40 g; 0.178 mol) and the whole is refluxed at 90° C. for 1.5 hours. After the temperature is returned to room temperature, the solvent is then distilled off under reduced pressure, and the residue is separated and purified by column chromatography (developing solution, ethyl acetate:hexane=1:5) to produce Ester 3 (25.15 g; 0.135 mol) of 98% in yield.

1. customis returned to room temperature
2. distillationthe solvent is then distilled off under reduced pressure
3. customthe residue is separated
4. custompurified by column chromatography (developing solution, ethyl acetate:hexane=1:5)