Ammonium formate → N-{5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(3-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}propoxy)phenyl]ethyl}amino)ethyl]-2-hydroxyphenyl}methanesulfonamide

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Reaction Conditions

Reaction Steps

N-{2-(benzyloxy)-5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(3-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}propoxy)phenyl]ethyl}amino)ethyl]phenyl}methanesulfonamide (Preparation 9, 100 mg, 0.11 mmol) was dissolved in ethanol (10 ml) and ammonium formate (68 mg, 1.07 mmol) and 10% palladium hydroxide on carbon (20 mg) added. The stirred reaction was heated at 90° C. for 2 hours, cooled to room temperature and filtered through Arbocel™, the filtrate was collected and the solvent removed in vacuo to furnish the title compound as a yellow glass, 98 mg.

Provenance & Evidence