Hydrochloric Acid → 4-{4-[4-(2-Aminoethyl)phenoxy]butyl}-2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenol bis hydrochloride salt

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Reaction Steps

tert-butyl{2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}carbamate (Preparation 12, 450 mg, 0.75 mmol) was dissolved in dichloromethane (10 ml), hydrogen chloride (2M in diethyl ether, 6 ml, 12 mmol) was added followed by ethanol (1 ml). After 3 days, solvents removed in vacuo to furnish the title compound as a yellow foam, 420 mg.

Provenance & Evidence