Ammonium formate → 6-(4-{3-[(1R)-3-(Diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)hexanenitrile

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Reaction Steps

6-{[(3E)-4-{4-(Benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}but-3-en-1-yl]oxy}hexanenitrile (Preparation 24, 935 mg, 1.65 mmol) was dissolved in ethanol (20 ml) and ammonium formate (1.90 g, 30.0 mmol) and 10% palladium hydroxide on carbon (190 mg) added. The reaction was heated under reflux for 1 hour, cooled to room temperature and the reaction filtered through Arbocel™, the filtrate solvent was removed in vacuo to furnish the title compound as a colourless oil, 783 mg.

Provenance & Evidence