反应详情

tert-butyl{2-[3-(2-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}ethoxy)phenyl]ethyl}carbamate (Preparation 37, 1.3 g, 2.0 mmol) dissolved in dichloromethane (5 ml) and hydrochloric acid (4M in dioxin) added. Mixture stirred at room temperature for 3 hours under nitrogen. Solvent was removed in vacuo, and residue dissolved in dichloromethane (100 ml) and aqueous sodium hydroxide (1M, 100 ml), aqueous separated and extracted with dichloromethane (100 ml). Combined organics were dried (magnesium sulphate) and the solvent was removed in vacuo to furnish the title compound as an oil, 880 mg.

1. customSolvent was removed in vacuo, and residue
2. dissolutiondissolved in dichloromethane (100 ml)
3. customaqueous sodium hydroxide (1M, 100 ml), aqueous separated
4. extractionextracted with dichloromethane (100 ml)
5. dry with materialCombined organics were dried (magnesium sulphate)
6. customthe solvent was removed in vacuo