Ammonium formate → HCID 57933219, compound

Participants

Reaction Conditions

Reaction Steps

N-[2-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[(2-{4-[(5-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}pentyl)oxy]phenyl}ethyl)amino]ethyl}phenyl]methanesulfonamide (Preparation 60, 350 mg, 0.37 mmol) was dissolved in ethanol (10 ml) and ammonium formate (1.0 g, 16 mmol) and 20% palladium hydroxide on carbon (250 mg) were added and heated to 90° C. for 1 hour. Reaction mixture was then cooled and filtered through Arbocel and the solvent removed in vacuo to furnish the title compound as a colourless oil, 250 mg.

Provenance & Evidence