tert-Butylsulfinamide, (S)-(-)- → HCID 178455880, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (5R)-5-methylheptan-2-one (3 g, 23.4 mmol) in tetrahydrofuran (10 ml) was added to a solution of (S)-2-methylpropane-2-sulfinamide and titanium tetraethoxide (9.8 ml, 46.8 mmol) in tetrahydrofuran. The solution was stirred at 50° C. for 20 hours. The reaction mixture was allowed to cool to room temperature, diluted with ethyl acetate (50 ml) and then poured into brine (100 ml).

Provenance & Evidence