Dimethyl Sulfoxide → HCID 131727727, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of oxalylchloride (0.15 mmol) in CH2Cl2 is added at −78° C. first DMSO (0.2 mmol) and then a solution of N-{(R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-3-[4-(6,6,6-trifluoro-1-hydroxy-hexyl)-phenyl]-propyl}-acetamide (0.1 mmol) in CH2Cl2. After stirring for 1 h at −78° C., triethylamine (0.7 mmol) is added and the mixture is warmed to RT. Quenching with water is followed by extraction with AcOEt. After drying (MgSO4), the solvent is evaporated.

Provenance & Evidence