4-Fluorophenyl isocyanate → N-(3-(6,7-Dimethoxyquinolin-4-yl)oxypropyl)-N'-(4-fluorophenyl)urea

HRID 1433389노트

반응식

HRID 1433389 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][CH2:16][CH2:17][CH2:18][NH2:19].[F:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][CH2:16][CH2:17][CH2:18][NH:19][C:28]([NH:27][C:24]1[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=1)=[O:29]

참가 물질

4

반응물 2

HCID 709554-Fluorophenyl isocyanateHCID 229362886,7-Dimethoxy-4-(3-aminopropoxy)quinoline

생성물 1

HCID 22936278N-(3-(6,7-Dimethoxyquinolin-4-yl)oxypropyl)-N'-(4-fluorophenyl)urea

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

6,7-Dimethoxy-4-(3-aminopropoxy)quinoline 150 mg (0.57 mM) and ethyl acetate (20 ml) were stirred at room temperature, and then 4-fluorophenyl isocyanate (0.078 ml, 0.68 mM) was added and the mixture was further stirred for 15 minutes. The precipitated solid was filtered out to obtain the target substance (92 mg) as a white solid.

후처리

  1. filtrationThe precipitated solid was filtered out
  2. customto obtain the target substance (92 mg) as a white solid

출처 및 근거

ORD 기록
ord-fab406c8a48d4676aebae53fad4a7853
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612092B2

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