HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-5-nitrothiophene | HCID 83222 | — |
| Reactant | 7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione | HCID 22936980 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene | HCID 58931211 | 76.9% |
Reaction Steps
7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione (14.3 g), 2-bromo-5-nitrothiophene (10 g), potassium carbonate (9.9 g) and dimethylformamide (150 ml) were stirred together at room temperature for 6 hours. Water was added, and the precipitated solid was filtered out and washed with water and then ethyl acetate to obtain 15.7 g of a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612092B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-9f7c43700d424c6ba43254f657a5f6b4 |
| Source note | uspto-grants-2009_11 |