HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycidyl tosylate, (R)- → 4-(4-amino-3-chlorophenoxy)-6-cyano-7-((2R)-oxiran-2-yl)methoxyquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycidyl tosylate, (R)- | HCID 154187 | — |
| Reactant | 4-(4-Amino-3-chlorophenoxy)-6-cyano-7-hydroxyquinoline | HCID 135829387 | — |
| Product | 4-(4-amino-3-chlorophenoxy)-6-cyano-7-((2R)-oxiran-2-yl)methoxyquinoline | HCID 86591467 | 16.8% |
Reaction Steps
The title compound (198 mg, 0.538 mmol, 16.8%) was obtained as light brown crystals from an 4-(4-amino-3-chlorophenoxy)-6-cyano-7-hydroxyquinoline crude product (1.00 g, 3.21 mmol) and (2R)-oxiran-2-ylmethyl 4-methyl-1-benzenesulfonate, by the same procedure as in Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612092B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-bb0881622a414abbae117977b388c3ab |
| Source note | uspto-grants-2009_11 |