HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1433608Generated: October 30, 2026
Diethylamine → N-(4-[6-Cyano-7-(3-diethylamino-2-hydroxypropoxy)quinolin-4-yloxy]-2-fluorophenyl}-N'-(4-fluorophenyl)urea
https://huagongshe.com/reaction/1433608
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | N-[4-(6-cyano-7-oxiranylmethoxyquinolin-4-yloxy)-2-fluorophenyl]-N'-(4-fluorophenyl)urea | HCID 22936552 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-[6-Cyano-7-(3-diethylamino-2-hydroxypropoxy)quinolin-4-yloxy]-2-fluorophenyl}-N'-(4-fluorophenyl)urea | HCID 67202569 | — |
Reaction Steps
After adding tetrahydrofuran (1 ml) and diethylamine (0.1 ml) to N-[4-(6-cyano-7-oxiranylmethoxyquinolin-4-yloxy)-2-fluorophenyl]-N′-(4-fluorophenyl)urea (100 mg), the mixture was heated at 50° C. for 30 minutes. The reaction solution was purified by NH silica gel column chromatography (ethyl acetate-methanol system) to obtain the title compound (32 mg) as light yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07612092B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-32ade3efeb894b9592f191c41a4a712d |
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| Source note | uspto-grants-2009_11 |
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