HCID 67202400, compound → Methyl 4-hydroxyfuro[2,3-B]pyridine-2-carboxylate

HRID 1433626Notes

Reaction equation

HRID 1433626 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([NH:10][CH:11]=[C:12]2[C:17](=[O:18])OC(C)(C)OC2=O)=[CH:8][CH:9]=1)=[O:4]>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[NH:10][CH:11]=[CH:12][C:17](=[O:18])[C:8]=2[CH:9]=1)=[O:4]

Participants

3

Reactant 1

HCID 67202400HCID 67202400, compound

Product 1

HCID 58931135Methyl 4-hydroxyfuro[2,3-B]pyridine-2-carboxylateYield 76.4%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Conditions

Temperature
200 °C

Procedure

After adding 5-[(2,2-dimethyl-4,6-dioxo-[1.3]dioxan-5-ylidenemethyl)amino]furan-2-carboxylic acid methyl ester (4.0 g) to Dowtherm A (30 ml), the mixture was heated and stirred at 200° C. for 1 hour. After cooling, the precipitated crystals were filtered out and washed with diethyl ether to obtain the title compound (2.0 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were filtered out
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-b6c36d3b1eba47d89cae7d0c737253f0
Source dataset
uspto-grants-2009_11
Patent number
US07612092B2

Reaction notes

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